This gameplay mechanic can also be used to target enemies, whom Spider-Man will attack automatically, or objects that Spider-Man will throw at enemies, incapacitating them for a few seconds and allowing Spider-Man to web them in order to subdue them for good.

The game also introduces a bullet time mechanic called Web-Rush, where players slow down time by holding a certain button and can select between different locations that Spider-Man will automatically move towards once the player releases the button. Players have access to all of Spider-Man's superhuman abilities, including web swinging and wall crawling. The missions are structured in a linear manner, but the player is free to explore the game's map in between missions and engage in various side activities.

Players take on the role of Spider-Man and complete missions-linear scenarios with set objectives-to progress through the story. The Amazing Spider-Man is a third person action-adventure video game, set in an open world based on Manhattan.